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A Warty Masquerade—Diagnosis
Arch Dermatol. 2005;141:515-520.
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Diagnosis: Acrokeratosis verruciformis of Hopf.
MICROSCOPIC FINDINGS AND CLINICAL COURSE
The biopsy specimen revealed "church spire" papillomatosis and acanthosis (Figure 2). There was no dyskeratosis, epidermal vacuolation, or significant inflammatory infiltrate.
Figure appears in full text version.
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A second biopsy specimen was obtained from lesional skin to detect the presence of human papillomavirus (HPV). The sample was tested by seminested polymerase chain reaction (PCR) analysis using HPV-2, B5, and NPR2 primers, which preferentially amplify HPV types associated with cutaneous lesions or epidermodysplasia verruciformis. Nested PCR analysis using MY09/MY11 and GP5+/6+ primer pairs, which is generally more useful for the detection of mucosal HPV types, was also performed. No HPV DNA was detected. The results of PCR analysis for  -globulin DNA, which was performed to assure sufficient sample quality, were positive.
DISCUSSION
Acrokeratosis verruciformis is an autosomal dominant disorder of keratinization.1 It usually develops in early childhood, with no sex preference.1 Clinically, patients present with verrucous lesions resembling flat warts on the dorsum of . . . [Full Text of this Article]
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Arch Dermatol. 2005;141(4):515-520.
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