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Intralesional Fluorouracil Injection in Infantile Digital Fibromatosis
Chang-Keun Oh, MD, PhD;
Hyo-Sung Son, MD;
Yoo-Wook Kwon, PhD;
Ho-Sun Jang, MD, PhD;
Kyung-Sool Kwon, MD, PhD
From the Department of Dermatology, Pusan National University College of Medicine, Busan, Korea (Drs Oh, Son, Jang, and K.-S. Kwon); and Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (Dr Y.-W. Kwon).
Arch Dermatol. 2005;141:549-550.
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REPORT OF A CASE
A 7-year-old Korean girl presented with an 8-month history of an erythematous hard plaque on her left hand. There was no history of trauma. On physical examination, a 1.4 x 0.8-cm firm plaque was observed on the ulnar surface of the left hand at the metacarpophalangeal level (Figure).
Figure appears in full text version.
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Figure. Plaque on the ulnar surface of the left hand. A, Well-defined erythematous firm plaque before treatment. B, One month after first injection. C, One month after second injection. D, Seven months after fifth injection.
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Histopathologic examination showed moderately cellular fibroblasts throughout the dermis. Hematoxylin-eosin staining revealed eosinophilic intracytoplasmic inclusion bodies in fibroblasts. The inclusions stained bright red with Masson trichrome and deep purple with phosphotungstic acid–hematoxylin. They were negative for alcian blue and periodic acid–Schiff.
THERAPEUTIC CHALLENGE
In the past, infantile digital fibromatosis . . . [Full Text of this Article]
SOLUTION
COMMENT
AUTHOR INFORMATION
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