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Gary S. Wood, MD

Arch Dermatol. 2005;141:632.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Classification and Prediction of Survival in Patients With the Leukemic Phase of Cutaneous T Cell Lymphoma
Kari L, Loboda A, Nebozhyn M, et al.
J Exp Med. 2003;197:1477-1488.

We have used cDNA arrays to investigate gene expression patterns in peripheral blood mononuclear cells from patients with leukemic forms of cutaneous T cell lymphoma, primarily Sezary syndrome (SS). When expression data for patients with high blood tumor burden (Sezary cells >60% of the lymphocytes) and healthy controls are compared by Student's t test, at P<.01, we find 385 genes to be differentially expressed. Highly overexpressed genes include Th2 cells-specific transcription factors Gata-3 and Jun B, as well as integrin beta1, proteoglycan 2, the RhoB oncogene, and dual specificity phosphatase 1. Highly underexpressed genes include CD26, Stat-4, and the IL-1 receptors. Message for plastin-T, not normally expressed in lymphoid tissue, is detected only in patient samples . . . [Full Text of this Article]

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AUTHOR INFORMATION

From the Department of Dermatology, University of Wisconsin, Madison

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