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Arch Dermatol. 2005;141:633-638.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Episodic angioedema with eosinophilia (Gleich syndrome).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histopathologic examination of the skin biopsy specimen showed a dense diffuse eosinophilic infiltrate in the upper reticular dermis, without signs of vasculitis or flame figures. A cervical lymph node revealed an eosinophilic infiltrate. Ophthalmologic and otorhinolaryngologic examinations showed edematous lacrimal glands and nasal mucosa, which, on microscopic examination, revealed numerous infiltrating eosinophils. Ultrasonography and computed tomographic scans showed multiple enlarged cervical, axillary, inguinal, and retroperitoneal lymph nodes. There was no evidence of cardiac or other visceral organ involvement. Laboratory tests revealed marked eosinophilia (eosinophils, 21.0x10³/µL [70%]; reference value, <0.6x10³/µL [reference range, 0%-6%]), hypoalbuminemia, increased erythrocyte sedimentation rate, and elevated levels of serum IgM, IgE, C-reactive protein, and eosinophil cationic protein. A bone marrow examination showed increased numbers of eosinophil precursors but no signs of malignancy.

The patient was treated symptomatically with oral antihistamines and a topical polydocanole preparation. Treatment with dapsone was not beneficial. . . . [Full Text of this Article]

DISCUSSION

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Jennifer Hehn, Eva-Bettina Bröcker, and Matthias Goebeler
Arch Dermatol. 2005;141(5):633-638.
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