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Cell-Mediated Immunologic Mechanism and Severity of TEN
Arch Dermatol. 2005;141:775-776.
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Toxic epidermal necrolysis (TEN) is a rare life-threatening disease with an incidence in all countries where it has been studied of about 1 case per million population per year.1 Although rare, TEN remains a disease of great interest for dermatologists and other physicians for 3 main reasons: high mortality and morbidity rates, dramatic death of the epidermis through a mechanism that is not fully understood, and the fact that this potentially fatal disease is most often the result of an "allergic" reaction to a medication.
The definition of TEN has not been universally established. In this issue of the ARCHIVES, Quinn et al2 define it as epidermal sloughing over 30% or more of the body surface area (BSA) associated with evidence of full-thickness "necrosis" of the epidermis on pathologic analysis. These criteria, as proposed 12 years ago by an international group of experts,3 have the advantage of high . . . [Full Text of this Article]
AUTHOR INFORMATION
Ousmane Faye, MD;
Janine Wechsler, MD;
Jean-Claude Roujeau, MD
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