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Improvement in Digital Flexibility and Dexterity Following Ingestion of Sildenafil Citrate (Viagra) in Limited Systemic Sclerosis
Anthony Yung, MB, ChB, FRACP;
Naomi Reay, MA, RGN;
Mark D. Goodfield, MD, FRCP
Departments of Dermatology (Drs Yung and Goodfield) and Rheumatology (Ms Reay), The Leeds General Infirmary, Leeds, England.
Arch Dermatol. 2005;141:831-833.
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REPORT OF A CASE
A 66-year old man with a 20-year history of limited systemic sclerosis and discoid lupus erythematosus–induced scarring alopecia presented to our clinic for follow-up. He had an antinuclear antibody ratio (Hep-2) of 1:80; homogeneous staining pattern; negative extractable nuclear antibody screen findings (anti-Sm, Anti-RNP, anti-Ro, and anti-La); anti–double-stranded DNA antibody value of 22 IU/L (normal, <50 IU/L); and negative anti-Scl-70 findings. He had no history of diabetes mellitus, ischemic heart disease, or peripheral vascular disease. His skin conditions had been stable for 6 years under treatment with 200 mg of hydroxychloroquine daily, 20 mg of omeprazole daily, 2% ketoconazole shampoo, clobetasol propionate as needed (intermittently) for scalp lesions of discoid lupus erythematosus, and 2 annual prostacyclin infusions in the winter season.
On examination, he was found to have sclerodactyly affecting all the digits of his hand . . . [Full Text of this Article]
CLINICAL CHALLENGE
SOLUTION
COMMENT
AUTHOR INFORMATION
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