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Arch Dermatol. 2005;141:897-902.

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Diagnosis: Primary follicular mucinosis (FM) (alopecia mucinosa).

MICROSCOPIC, LABORATORY, AND RADIOGRAPHIC FINDINGS AND CLINICAL COURSE

Histopathologic examination of the skin biopsy specimen showed mucin accumulation within sebaceous glands and the external root sheaths of hair follicles. Also, the dermis contained a mixed inflammatory infiltrate of lymphocytes, histiocytes, and eosinophils (Figure 2). The hair follicles were also markedly dilated and showed cyst formation (Figure 3). Mucicarmine staining revealed cystic spaces filled with mucin. No epidermotropism, Pautrier microabscesses, or atypical lymphocytes with mitotic figures were observed. Physical examination and laboratory investigations, including blood tests, radiography of the chest, and ultrasonography of the abdomen, revealed no abnormalities.

Figure appears in full text version. Figure 2.

Figure appears in full text version. Figure 3.

Based on the clinical and microscopic features, the patient was diagnosed as having primary FM (alopecia mucinosa). He completed a 1-month course of doxycycline (100 mg twice daily), but new lesions developed during this therapy. He then began a 1-month course of isotretinoin (1 mg/kg per day). The infiltration in the centers of . . . [Full Text of this Article]

DISCUSSION

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Arch Dermatol. 2005;141(7):897-902.
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