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Chronic Infiltrates and Persisting Ulcerations on the Arms and LegsDiagnosis
Arch Dermatol. 2005;141:897-902.
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Diagnosis: Mycobacterium haemophilum infection.
MICROSCOPIC AND LABORATORY FINDINGS AND CLINICAL COURSE
Histologic examination of the biopsy specimen revealed a dense, diffuse infiltrate in the dermis and subcutaneous tissue consisting almost exclusively of granulocytes. Because there was concern regarding an infectious process, a Ziehl-Neelsen stain was performed, which showed numerous acid-fast bacilli (Figure 4). Culture of tissue on Jensen-Löwenstein agar did not yield mycobacteria, but acid-fast bacilli were found in the sputum sample as well as in the smear from an ulcerative lesion on the hand.
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On further questioning, the patient admitted that he had deliberately increased the recommended dosage of prednisone on many occasions (up to 150 mg/d) because of the psychotropic effects. After the histologic diagnosis of mycobacterial infection was made, his therapy was changed to a combination of isoniazid, ethambutol hydrochloride, and rifampin. During the following days, he also developed pneumonia with Aspergillus fumigatus, and despite immediate transfer to an intensive care unit, he . . . [Full Text of this Article] DISCUSSION
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Arch Dermatol. 2005;141(7):897-902.
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