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VIGNETTES
Recalcitrant Cutaneous Sarcoidosis Responding to Infliximab
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Sarcoidosis is a multisystem disease, manifesting with cutaneous involvement in approximately 25% of patients.1 Lesions present in a wide variety of forms, including lupus pernio, violaceous papules and plaques, subcutaneous nodules, alopecia, ichthyosis, or verrucous growths. We describe a woman with cutaneous sarcoidosis refractory to treatment with multiple systemic agents who improved dramatically with infliximab therapy.
Report of a Case
A 51-year-old white woman presented with a painful itchy rash of 1 year’s duration (Figure 1). Her medical history was significant for an extensive hot-water burn 13 years prior that required skin grafting. Review of systems was significant for dull muscle aches.
Figure appears in full text version.
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Figure 1. Clinical involvement before infliximab therapy.
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Cutaneous examination revealed multiple violaceous papules and plaques. Histologic analysis of punch biopsy specimens revealed multiple dermal noncaseating granulomas, confirming a diagnosis of sarcoidosis. Standard laboratory findings from a complete blood cell count and liver and renal function testing were normal. The angiotension-converting . . . [Full Text of this Article]
Comment
AUTHOR INFORMATION
Michael P. Heffernan, MD;
Milan J. Anadkat, MD
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