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Arch Dermatol. 2005;141:1035-1040.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Subcutaneous panniculitic T-cell lymphoma (SPTCL).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histopathologic examination of the skin biopsy specimen demonstrated heavy infiltrates of monomorphous atypical lymphoid cells rimming individual adipocytes, apoptosis, karyorrhexis, and areas of angiocentrism and neurotropism (accounting for the hypoesthesias). On immunohistochemical analysis, the lymphocytes were strongly positive for CD45RO and negative for CD20. Bone marrow analysis was performed and revealed leukoerythrophagocytosis by macrophages. The histopathologic features of the case were consistent with the diagnosis of malignant lymphoma involving the subcutis and specifically with SPTCL.

Despite aggressive chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and supportive intensive care in this case, hemophagocytic syndrome developed, leading to multiple organ failure and death.

DISCUSSION

Subcutaneous panniculitic T-cell lymphoma is a rare distinct subtype of peripheral clonal T-cell lymphoma, characterized by neoplastic lymphocytes invading the subcutis. It frequently mimics lobular panniculitis, both clinically and histologically. Originally described by Gonzales et al¹ in 1991, SPTCL has become a definite entity in the 2005 World . . . [Full Text of this Article]

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Arch Dermatol. 2005;141(8):1035-1040.
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