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Multinodular Plaque in a Young AdultDiagnosis
Arch Dermatol. 2005;141:1035-1040.
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Diagnosis: Giant folliculosebaceous cystic hamartoma (FSCH).
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Histopathologic examination of the biopsy specimen revealed an epidermis with mild hyperplasia and mild hyperkeratosis. Several infundibulocystic structures with surrounding well-developed, mature sebaceous lobules emanating from some of the cyst walls were evident in the dermal stroma. The cystic structures were lined by stratified squamous epithelium with ortholemmal keratinization. Vascularized fibrous stroma surrounding the structures was also seen. The patient was referred for surgical resection.
DISCUSSION
Folliculosebaceous cystic hamartoma is a unique benign tumor that is formed from follicular, sebaceous, and mesenchymal elements. In 1991, Kimura et al1 described 5 patients with FSCH lesions, which appeared as flesh-colored exophytic papules or nodules. Fewer than 25 cases have been reported to date. Yamamoto et al2 described a case involving a giant variant of FSCH. Folliculosebaceous cystic hamartomas are most commonly found on the head, especially in the central part of the face and nose, although a genital variant has been reported as . . . [Full Text of this Article]
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Arch Dermatol. 2005;141(8):1035-1040.
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