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Dehisced Wound in a Heart Transplant RecipientDiagnosis
Arch Dermatol. 2005;141:1035-1040.
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Diagnosis: Primary cutaneous aspergillosis.
MICROSCOPIC FINDINGS AND CLINICAL COURSE
At all levels of the dermis, there were dilated blood vessels that were engorged with erythrocytes (Figure 2). Areas of necrosis were present in the overlying epidermis. In the interstitial dermis, there was a sparse infiltrate composed of mononuclear cells associated with hemorrhage. On hematoxylin-eosin staining, mycelia were identified within the lumina and infiltrating the walls of vessels near the dermal-subcutaneous border (Figure 3). Gomori methenamine silverstained sections revealed abundant mycelial forms throughout the dermis and subcutis (Figure 4). The hyphae were septate, measuring 3 to 5 µm in width, with dichotomous, acute-angle branching. A preliminary diagnosis of angioinvasive aspergillosis was made. Amphotericin B therapy was initiated, but the patient died of multiorgan failure due to presumed fungal sepsis 1 day later. Culture of the skin biopsy specimen later yielded Aspergillus flavus.
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DISCUSSION
Aspergillus species are ubiquitous saprophytic . . . [Full Text of this Article]
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Dehisced Wound in a Heart Transplant RecipientQuiz Case
Adam S. Geyer, Lindy P. Fox, Asher Rabinowitz, and Marc E. Grossman
Arch Dermatol. 2005;141(8):1035-1040.
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