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Defining the T-Cell Clone

Arch Dermatol. 2005;141:1159-1160.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of the ARCHIVES, Juarez et al¹ studied the prognostic value of nodal T-cell receptor gene rearrangement analysis in cutaneous T-cell lymphoma (CTCL). They found that the predictive outcome value of T-cell clonality by any method was inferior to that of a simple clinical skin assessment (T stage). They also found that clinical detection of lymphadenopathy (N1 stage) was pragmatically more relevant than finding a T-cell clone by polymerase chain reaction (PCR). Furthermore, they concluded that the old Southern blot clonality test, which has been broadly replaced by more practical and sensitive PCR-based analysis, was more effective than PCR in predicting a poor outcome. All 15 study patients with positive clonality by Southern blot died in less than 10 years.

What can we learn from this study on our present understanding of CTCL? And how can we integrate these conclusions into the management of patients with . . . [Full Text of this Article]

AUTHOR INFORMATION
Joan Guitart, MD

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Analysis of T-Cell Receptor Gene Rearrangement for Predicting Clinical Outcome in Patients With Cutaneous T-Cell Lymphoma: A Comparison of Southern Blot and Polymerase Chain Reaction Methods
Thaddeus Juarez, Scott N. Isenhath, Nayak L. Polissar, Daniel E. Sabath, Brent Wood, Deena Hanke, Claire L. Haycox, Gary S. Wood, and John E. Olerud
Arch Dermatol. 2005;141(9):1107-1113.
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