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A Papule Arising in Irradiated Breast Tissue—Diagnosis
Arch Dermatol. 2006;142:101-106.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Diagnosis: Atypical vascular lesion (AVL).
MICROSCOPIC FINDINGS
Histopathologic examination of the papule revealed a relatively well-circumscribed vascular proliferation consisting of dilated and angulated vascular channels lined by a single layer of widely spaced inconspicuous endothelial cells with only mild cytologic atypia. Focal branching of the vascular channels and projections of endothelium-covered stroma into the vascular lumina were seen. There was a mild associated chronic inflammatory infiltrate. The lesion was limited to the superficial to midreticular dermis and did not infiltrate the deep dermis or subcutaneous tissue.
DISCUSSION
The histologic description of the lesion in the present case—a superficially dermal-based, relatively well-circumscribed vascular proliferation composed of dilated vascular channels that were lined by inconspicuous endothelial cells without significant cytological atypia—was consistent with an AVL. This entity has been described in women who were previously treated with radiation therapy for breast carcinoma.1-4 It typically presents as a discrete 3- to 4-mm pink papule on the surface of irradiated tissue. The . . . [Full Text of this Article]
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Arch Dermatol. 2006;142(1):101-106.
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