 |
|
Multiple Annular Plaques in an Infant—Diagnosis
Arch Dermatol. 2006;142:1351-1356.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
Diagnosis: Neonatal lupus erythematosus (NLE).
MICROSCOPIC FINDINGS, LABORATORY FINDINGS, AND CLINICAL COURSE
Histologic sections demonstrated occasional necrotic keratinocytes within the epidermis and vacuolar alteration of the basal layer. A superficial and bandlike infiltrate of lymphocytes and histiocytes and mucin deposition were noted in the dermis. The patient's serum sample was positive for antinuclear, anti-SSA/Ro, and anti-SSB/La antibodies and negative for anti-U1RNP, anti-Smith, anti–Jo-1, and anti–Scl-70 antibodies. Her electrocardiograms revealed no abnormalities. Serologic studies of the mother's serum sample revealed anti-SSA/Ro and anti-SSB/La antibodies as well as an antinuclear antibody titer of 1:320 in a speckled pattern. The mother had no symptoms of autoimmunity.
DISCUSSION
Neonatal lupus erythematosus is an uncommon disease in which newborns have circulating anti-SSA/Ro and/or anti-SSB/La, but rarely anti-U1RNP, autoantibodies that are acquired transplacentally from the mother.1 The incidence of NLE is approximately 1 in 12 500 live births.1 About 50% of symptomatic neonates will present with cutaneous symptoms, with the remainder having cardiac disease; some 10% have both.2 Most manifestations . . . [Full Text of this Article]
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
Multiple Annular Plaques in an Infant—Quiz Case
Brian M. Levenson, K. Robin Carder, and Mai P. Hoang
Arch Dermatol. 2006;142(10):1351-1356.
EXTRACT
| FULL TEXT
|
