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  Vol. 142 No. 10, October 2006 TABLE OF CONTENTS
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Multiple Annular Plaques in an Infant—Diagnosis

Arch Dermatol. 2006;142:1351-1356.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Neonatal lupus erythematosus (NLE).

MICROSCOPIC FINDINGS, LABORATORY FINDINGS, AND CLINICAL COURSE

Histologic sections demonstrated occasional necrotic keratinocytes within the epidermis and vacuolar alteration of the basal layer. A superficial and bandlike infiltrate of lymphocytes and histiocytes and mucin deposition were noted in the dermis. The patient's serum sample was positive for antinuclear, anti-SSA/Ro, and anti-SSB/La antibodies and negative for anti-U1RNP, anti-Smith, anti–Jo-1, and anti–Scl-70 antibodies. Her electrocardiograms revealed no abnormalities. Serologic studies of the mother's serum sample revealed anti-SSA/Ro and anti-SSB/La antibodies as well as an antinuclear antibody titer of 1:320 in a speckled pattern. The mother had no symptoms of autoimmunity.

DISCUSSION

Neonatal lupus erythematosus is an uncommon disease in which newborns have circulating anti-SSA/Ro and/or anti-SSB/La, but rarely anti-U1RNP, autoantibodies that are acquired transplacentally from the mother.1 The incidence of NLE is approximately 1 in 12 500 live births.1 About 50% of symptomatic neonates will present with cutaneous symptoms, with the remainder having cardiac disease; some 10% have both.2 Most manifestations . . . [Full Text of this Article]



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RELATED ARTICLE

Multiple Annular Plaques in an Infant—Quiz Case
Brian M. Levenson, K. Robin Carder, and Mai P. Hoang
Arch Dermatol. 2006;142(10):1351-1356.
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