This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Diagnosis  • Pediatrics  • Neonatology and Infant Care  • Dermatologic Disorders, Other  • Alert me on articles by topic

Arch Dermatol. 2006;142:1351-1356.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Neonatal lupus erythematosus (NLE).

MICROSCOPIC FINDINGS, LABORATORY FINDINGS, AND CLINICAL COURSE

Histologic sections demonstrated occasional necrotic keratinocytes within the epidermis and vacuolar alteration of the basal layer. A superficial and bandlike infiltrate of lymphocytes and histiocytes and mucin deposition were noted in the dermis. The patient's serum sample was positive for antinuclear, anti-SSA/Ro, and anti-SSB/La antibodies and negative for anti-U1RNP, anti-Smith, anti–Jo-1, and anti–Scl-70 antibodies. Her electrocardiograms revealed no abnormalities. Serologic studies of the mother's serum sample revealed anti-SSA/Ro and anti-SSB/La antibodies as well as an antinuclear antibody titer of 1:320 in a speckled pattern. The mother had no symptoms of autoimmunity.

DISCUSSION

Neonatal lupus erythematosus is an uncommon disease in which newborns have circulating anti-SSA/Ro and/or anti-SSB/La, but rarely anti-U1RNP, autoantibodies that are acquired transplacentally from the mother.¹ The incidence of NLE is approximately 1 in 12 500 live births.¹ About 50% of symptomatic neonates will present with cutaneous symptoms, with the remainder having cardiac disease; some 10% have both.² Most manifestations . . . [Full Text of this Article]

RELATED ARTICLE

Multiple Annular Plaques in an Infant—Quiz Case
Brian M. Levenson, K. Robin Carder, and Mai P. Hoang
Arch Dermatol. 2006;142(10):1351-1356.
EXTRACT | FULL TEXT