Diagnosis: Eccrine angiomatous hamartoma (EAH).
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Histopathologic examination of the excised specimen revealed a collection of well-differentiated eccrine ducts and glands mixed with dilated and collapsed vascular spaces, as well as abundant adipose tissue and epidermal inclusion cysts. The lesion was excised without complication, and there has been no recurrence to date.
DISCUSSION
Eccrine angiomatous hamartoma is an uncommon benign tumor that usually occurs on the lower extremities and is congenital or appears in early childhood. The lesions are usually nodular and solitary and can be painful. The pain may be due to proliferation of nerve tissue. The lesions may also demonstrate hyperhidrosis, especially when they are manipulated.
Pilar and adipose structures are uncommon features of EAH.1-3 The secretory eccrine components stain with S100 protein, carcinoembryonic antigen, epithelial membrane antigen, and CAM 5.2. The ductal components stain strongly for carcinoembryonic antigen and cytokeratin 1 and weakly for epithelial membrane antigen. The vascular structures stain with antiUlex . . . [Full Text of this Article]