This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Dermatology  • Dermatologic Disorders  • Diagnosis  • Dermatologic Disorders, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Arch Dermatol. 2006;142:1501-1506.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Cutaneous Rosai-Dorfman disease (RDD).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Both biopsy specimens demonstrated dense dermal infiltrates of histiocytes with abundant, focally foamy cytoplasm. The cytoplasm of some of the histiocytes contained lymphocytes, plasma cells, and neutrophils (emperipolesis). There was no significant histiocytic atypia. The histiocytes were surrounded by a patchy lymphocytic and plasma cell infiltrate. Immunohistochemical staining revealed that the histiocytes were positive for S100 protein and CD68 and negative for CD1a. Oral prednisone therapy was initiated at a dosage of 60 mg/d for 3 weeks and then tapered over the ensuing 3 weeks. After 6 weeks of treatment, the lesions had nearly resolved.

DISCUSSION

Rosai-Dorfman disease, which was first recognized as a distinct clinicopathologic entity in 1969, was formerly referred to as sinus histiocytosis with massive lymphadenopathy. It is characterized by a benign proliferative disorder of histiocytes¹ and is most commonly confined to cervical or other lymph nodes. Although RDD occurs most commonly with nodal involvement alone, it . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Multiple Nodules and Plaques on the Face and Trunk—Quiz Case
David G. Wartman, Ann Perry, and Andrew E. Werchniak
Arch Dermatol. 2006;142(11):1501-1506.
EXTRACT | FULL TEXT