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Arch Dermatol. 2006;142:1643-1648.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Cheilitis glandularis (CG) simplex.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Hematoxylin-eosin–stained sections revealed mucosal acanthosis and parakeratosis, with small foci of scale crust. There were clusters of cells within the epidermis that were filled with basophilic material, which was confirmed to be mucin deposition on alcian blue staining. Within the dermis, there was a dense lichenoid and diffuse inflammatory infiltrate composed of lymphocytes, histiocytes, plasma cells, and numerous eosinophils, with exocytosis into the overlying mucosa. No granulomas were identified. Stains, including periodic acid–Schiff, Steiner, and Warthin-Starry, were negative for microorganisms.

A trial of 0.1% tacrolimus ointment (Protopic) twice daily was initiated. After 6 weeks, the lower lip looked normal. At 4 months, the lip still appeared normal, and there were no intervening flares. Tacrolimus therapy was then discontinued. The use of bland emollients such as petrolatum was recommended.

DISCUSSION

Cheilitis glandularis is a rare, chronic inflammatory disorder of unknown etiology. It presents with swelling, eversion, and ulceration and usually involves only . . . [Full Text of this Article]