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Successful Adjuvant Treatment of Recalcitrant Epidermolysis Bullosa Acquisita With Anti-CD20 Antibody Rituximab
Enno Schmidt, MD, PhD;
Sandrine Benoit, MD;
Eva-Bettina Bröcker, MD;
Detlef Zillikens, MD;
Matthias Goebeler, MD
University of Würzburg, Würzburg (Drs Schmidt, Benoit, Bröcker, and Goebeler), University of Lübeck, Lübeck (Dr Zillikens), and University Hospital Mannheim, University of Heidelberg (Dr Goebeler), Germany
Arch Dermatol. 2006;142:147-150.
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REPORT OF A CASE
A 46-year-old man of Turkish origin presented with a 4-month-history of blisters on both erythematous and apparently normal skin as well as erosions on oral mucous membranes. At a body weight of 75 kg, he had been treated with dapsone (150 mg/d) and prednisolone (initially 250 mg/d, then 100 mg/d), while new lesions continued to arise. After 1 month, dapsone was changed to azathioprine (100 mg/d). On physical examination, multiple blisters and extensive erosions on erythematous skin were seen on the entire integument, especially on the chest, abdomen, upper back area, and dorsal aspect of both hands (Figure 1A). Scars and milia were found on the upper back area, and postinflammatory hyperpigmentation had developed at the sites of healed lesions. Also, erosions were present on the hard palate, the left buccal mucosa, . . . [Full Text of this Article]
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Clinical Response of Severe Mechanobullous Epidermolysis Bullosa Acquisita to Combined Treatment With Immunoadsorption and Rituximab (Anti-CD20 Monoclonal Antibodies)
Niedermeier et al.
Arch Dermatol 2007;143:192-198.
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