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Treatment of Generalized Lichen Planus With Alefacept
David P. Fivenson, MD;
Barbara Mathes, MD
Fivenson Dermatology, Ann Arbor, Mich (Dr Fivenson), and Biogen Idec, Inc, Cambridge, Mass (Dr Mathes)
Arch Dermatol. 2006;142:151-152.
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REPORT OF CASES
CASE 1
A 25-year-old white woman with a 2-year history of lichen planus (LP) presented with widespread violaceous, hyperpigmented, pruritic papules involving the upper part of the arms, forearms, abdomen, thighs, lower part of the legs, and lower back area (Figure, A). There were several lacy white patches without ulceration on the buccal mucosa of the mouth, but there was no vulvovaginal or scalp involvement. Previous treatments had included antihistamines, hydroxychloroquine sulfate, topical tacrolimus, systemic and topical corticosteroids, cyclosporine, griseofulvin, and narrow-band UV-B. Each systemic therapy was used for at least 3 months. The results of hepatitis screening were negative. The patient had no known medical allergies, and her medical history was unremarkable.
Figure appears in full text version.
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Figure. Patient 1 before (A) and after (B) treatment with alefacept. A, Raised erythematous and violaceous papules on the posterior aspect of the calf. B, After 12 weeks of alefacept . . . [Full Text of this Article]
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CASE 2
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
AUTHOR INFORMATION
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ABSTRACT
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