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Arch Dermatol. 2006;142:235-240.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Acute febrile neutrophilic dermatosis (Sweet syndrome [SS]).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Microscopic examination showed a dense perivascular and interstitial infiltrate of neutrophils with leukocytoclasia. Rare lymphocytes and eosinophils were observed. There was no evidence of fibrinoid changes in the vasculature. Atypical changes suggestive of leukemia were not seen. The histologic changes were consistent with a diagnosis of SS.

The patient was treated with prednisone therapy, which was initiated at a dosage of 60 mg/d and tapered over 3 weeks, and 0.1% triamcinolone acetonide ointment; however, she required continued treatment with broad-spectrum antibiotics and G-CSF because of persistent fever and neutropenia. Her lesions resolved over the next 3 weeks, and she was subsequently treated with both cytarabine and G-CSF, without a recurrence of SS.

DISCUSSION

Sweet syndrome was first described in 1964.¹ It is characterized by boggy, erythematous plaques and papules that may be become severely edematous, resulting in a pseudovesicular or pseudopustular appearance.² The lesions of SS occur most often on the . . . [Full Text of this Article]

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Arch Dermatol. 2006;142(2):235-240.
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