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COMMENTS AND OPINIONS
A Seeming Failure of Logic
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I am perplexed by what seems to be a contradiction in conclusions drawn by the members of the Melanoma Center at the University of California, San Francisco, concerning prognosis of primary cutaneous melanoma. In a recent issue of the ARCHIVES, Shaikh et al write as follows1(p739):
The presence of microsatellites is intimately tied to other markers of melanoma aggressiveness. Microsatellites appear to predict locoregional relapse and RFS [relapse-free survival] but neither distant metastasis nor OS [overall survival].
However, 4 years ago, in the ARCHIVES, Kashani-Sabet et al made these statements2(p1172):
The results of our analysis clearly indicate the independent role of vascular involvement in the prognostic assessment of patients with melanoma. The presence of vascular involvement was associated with an increased risk of melanoma relapse and death. Interestingly, involvement of the tumor vasculature, which is believed to represent largely lymphatic vessels, was predictive of . . . [Full Text of this Article]
AUTHOR INFORMATION
A. Bernard Ackerman, MD
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