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COMMENTS AND OPINIONS
A Seeming Failure of Logic—Reply
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In reply
We appreciate Ackerman's care in reading our article1 as well as the opportunity to clarify the definitions for the different prognostic factors examined in patients with primary cutaneous melanoma. As indicated in the article's "Methods" section,1(p740) microsatellites were
strictly defined as discrete nest(s) of tumor cells distinctly separated by a minimum of 0.5 mm (by ocular micrometer) from the main body (vertical growth phase) of the tumor by a layer of collagen or subcutaneous fat.
As indicated elsewhere in the "Methods" section, "care was taken to distinguish between microsatellites and . . . vascular involvement."1(p740) The phenomenon of vascular involvement had been previously defined,2 and, owing to space constraints, was not redefined in this article. Vascular involvement has been defined to include both (1) vascular invasion, with tumor cells within the wall or lumens of endothelial-lined vessels, and (2) uncertain, or incipient vascular invasion, with melanoma cells immediately adjacent to the endothelium, . . . [Full Text of this Article]
AUTHOR INFORMATION
Mohammed Kashani-Sabet, MD;
Richard W. Sagebiel, MD
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