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VIGNETTES
Eyelash Trichomegaly Associated With Systemic Tacrolimus
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Report of a Case
A 35-year-old woman with hepatitis B underwent orthotopic heart transplantation for congestive heart failure secondary to congenital heart defects. Postoperative immunosuppression included treatment with tacrolimus, mycophenolate mofetil, and prednisone. Of note, the patient did not receive cyclosporine.
Ten weeks after transplantation, the patient was seen by the dermatology service for an allergic contact dermatitis reaction to tape. At that time, the patient was noted to have eyelash trichomegaly (eyelashes measuring approximately 1.3 cm) that she noted about 8 weeks after receiving the transplant and starting immunosuppressant therapy (Figure). We propose that the eyelash trichomegaly was induced by tacrolimus.
Figure appears in full text version.
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Figure. Eyelash trichomegaly: approximate eyelash length,1.3 cm.
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Comment
Tacrolimus and cyclosporine have a similar mechanism of action, namely, inhibition of T-lymphocyte activation via calcineurin inhibition. The 2 drugs also induce some of the same adverse effects, including nephrotoxic and neurotoxic effects, increased serum uric acid levels, increased risk of lymphoproliferative disorders, . . . [Full Text of this Article]
AUTHOR INFORMATION
Kimberley M. Ward, MD;
Channing Barnett, MD;
Lindy P. Fox, MD;
Marc E. Grossman, MD
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