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VIGNETTES
Lack of Efficacy of Tacrolimus in the Treatment of Vitiligo in the Absence of UV-B Exposure
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The best results in vitiligo treatment with tacrolimus ointment have been obtained in summer and on UV light–exposed areas, which suggests that UV light enhances the efficacy of tacrolimus ointment.1-5 We performed a prospective intra-individual left/right comparison pilot study to evaluate the efficacy of 0.1% tacrolimus ointment as true monotherapy with no UV light exposure (artificial or natural).
Methods
Nine consecutive patients, each with at least 1 pair of symmetrical patches of vitiligo with similar evolution, were included in the study (Table 1). For each patient, 2 symmetrical target lesions were chosen in areas covered by clothes and protected from UV exposure. The entire study was performed in winter (December to February), and patients were asked to avoid UV exposure on the treated areas during the entire length of the study. Each lesion was treated twice daily with the 0.1% tacrolimus ointment (Protopic; Fujisawa Healthcare Inc, Deerfield, Ill) for . . . [Full Text of this Article]
Results
Comment
AUTHOR INFORMATION
Nima Ostovari, MD;
Thierry Passeron, MD;
Jean-Philippe Lacour, MD;
Jean-Paul Ortonne, MD
RELATED LETTERS
Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure
Kabir Sardana, Premanshu Bhushan, and Vijay Kumar Garg
Arch Dermatol. 2007;143(1):119.
EXTRACT
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Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure—Reply
Thierry Passeron and Jean-Paul Ortonne
Arch Dermatol. 2007;143(1):120.
EXTRACT
| FULL TEXT
RELATED ARTICLES
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Lisa B. Travis, Jeffrey M. Weinberg, and Nanette B. Silverberg
Arch Dermatol. 2003;139(5):571-574.
EXTRACT
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A Double-blind Randomized Trial of 0.1% Tacrolimus vs 0.05% Clobetasol for the Treatment of Childhood Vitiligo
Veronica Lepe, Benjamin Moncada, Juan Pablo Castanedo-Cazares, Maria Bertha Torres-Alvarez, Carlos A. Ortiz, and Antonio B. Torres-Rubalcava
Arch Dermatol. 2003;139(5):581-585.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure
Sardana et al.
Arch Dermatol 2007;143:119-119.
FULL TEXT
Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure--Reply
Passeron and Ortonne
Arch Dermatol 2007;143:120-120.
FULL TEXT
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