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COMMENTS AND OPINIONS
T-Cell Clonality of Undetermined Significance
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In a recent article and an accompanying editorial in the ARCHIVES, Gniadecki and Lukowsky1 and Burg et al2 introduced the term T-cell dyscrasia of undetermined significance. The concept of monoclonal T-cell expansion of undetermined significance, however, was already introduced in 19923; it was strengthened in 1994 by the description of a T-cell equivalent of benign monoclonal gammopathy in healthy, elderly humans.4 T-cell clonality of undetermined significance (TCCUS) in different skin conditions was reported by us in 2001.5
In contrast to Gniadecki and Lukowsky,1 we hold that TCCUS is not confined to erythroderma. We identified blood T-cell clones not related to skin T-cell clones in patients with parapsoriasis6 and Jessner lymphocytic infiltration of the skin. In contrast, monoclonal T-cell populations in the blood of early-stage6 as well as advanced7 mycosis fungoides patients were identical to skin clones. Therefore, TCCUS should be diagnosed on identification of a monoclonal . . . [Full Text of this Article]
AUTHOR INFORMATION
Claus-Detlev Klemke, MD;
Nina Poenitz, MD;
Edgar Dippel, MD;
Michael Hummel, PhD;
Harald Stein, MD;
Sergij Goerdt, MD
RELATED ARTICLES
Monoclonal T-Cell Dyscrasia of Undetermined Significance Associated With Recalcitrant Erythroderma
Robert Gniadecki and Ansgar Lukowsky
Arch Dermatol. 2005;141(3):361-367.
ABSTRACT
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Dyscrasias With "Undetermined Significance"
Günter Burg, Reinhard Dummer, and Werner Kempf
Arch Dermatol. 2005;141(3):382-384.
EXTRACT
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