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Arch Dermatol. 2006;142:641-646.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Unilateral telangiectasia macularis eruptiva perstans (TMEP).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

The lesional biopsy specimen, which was compared with one from unaffected skin, revealed dilated upper dermal vessels with a discrete perivascular cellular infiltrate with increased mast cell numbers (range, 10-20 per high-power field) on Giemsa staining. Routine blood tests (including serum tryptase levels), abdominal ultrasound, and bone scintigraphy revealed no abnormalities. There were significant increases in the 24-hour urinary excretion of N-methylhistamine (355 µg [reference value, <172 µg]) and 1-methyl-4-imidazoleacetic acid (27.3 mg [reference value, <4.5 mg]). The overall picture was consistent with TMEP with a unilateral distribution.

Treatment was symptomatic. The patient was advised to avoid the specific triggers that might stimulate mast cell degranulation. H₁ antihistamines were administered to provide relief of flushing (ebastine, 20 mg/d, plus hydroxyzine hydrochloride, 50 mg/d). After 2 years of follow-up, there were no signs of systemic involvement.

DISCUSSION

Mastocytosis is a rare disease that is characterized by a primary pathologic increase in . . . [Full Text of this Article]

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Arch Dermatol. 2006;142(5):641-646.
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