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VIGNETTES
Peginterferon Alfa-2b for Mycosis Fungoides
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Currently, peginterferon alfa-2b plus ribavirin has been shown to be the best available therapy for patients with chronic hepatitis C virus (HCV) infection.1 Peginterferon alfa-2b (a 12-kDa linear polyethylene glycol moiety) plus ribavirin produces a significantly improved and sustained antiviral response compared with interferon alfa-2b plus ribavirin.1 Peginterferon alfa-2b has an extended serum half-life that provides constant viral suppression for 7 days, thus allowing once-weekly dosing and an enhanced clinical efficacy.1 While interferon alfa-2b has been used to treat T-cell lymphoma,2-3 we report herein the significant efficacy of peginterferon alfa-2b for treatment of skin lesions caused by mycosis fungoides (MF).
A 67-year-old Japanese man was referred to our hospital with a 6-month history of multiple, asymptomatic brown-red colored scaly erythematous macules and plaques over his arms and legs (Figure, A and B). He had not received any medications prior to the onset of his skin eruption. A skin biopsy . . . [Full Text of this Article] AUTHOR INFORMATION
Teruki Yanagi, MD;
Tadamichi Shimizu, MD, PhD;
Hideyuki Ujiie, MD;
Miki Ito, MD;
Riichiro Abe, MD, PhD;
Yukiko Tsuji-Abe, MD, PhD;
Shuhei Hige, MD, PhD;
Hiroshi Shimizu, MD, PhD
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