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Sam Gibbs, MD

Arch Dermatol. 2006;142:767-768.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Commentary on: Treatment of skin papillomas with topical -lactalbumin–oleic acid
Gustafsson L, Leijonhufvud I, Aronsson A, Mossberg AK, Svanborg C
N Engl J Med. 2004;350:2663-2672

Question: Is -lactalbumin–oleic acid (also known as HAMLET [human -lactalbumin made lethal to tumor cells]) effective as a treatment for cutaneous viral warts?

Design: A randomized, placebo-controlled double-blind trial converting to an open label study after 3 months.

Setting: University dermatology department in Lund, Sweden.

Patients: Forty adults and children with refractory warts (defined as "papillomas resistant to conventional treatments"). Nine of the 40 patients were receiving immunosuppressive drugs.

Intervention: An aqueous solution of 0.7mM -lactalbumin–oleic acid was applied to all lesions and occluded with a hydrocolloid dressing daily for 3 weeks. An identical-appearing solution of normal saline was used for patients in the placebo arm. In the much longer open-label phase of the trial, 34 patients received a further 3 weeks . . . [Full Text of this Article]

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AUTHOR INFORMATION
Ipswich Hospital, Ipswich, England

RELATED LETTER

Evidence-Based Dermatology: Some Problems With Research
Michael J. Sladden
Arch Dermatol. 2006;142(12):1650-1653.
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Evidence-Based Dermatology: Some Problems With Research
Sladden
Arch Dermatol 2006;142:1650-1653.
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