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Arch Dermatol. 2006;142:775-780.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Disseminated molluscum contagiosum (MC) in hyper-IgE syndrome.

MICROSCOPIC AND LABORATORY FINDINGS AND CLINICAL COURSE

The biopsy specimen revealed a hypertrophied and hyperplastic epidermis consisting of enlarged keratinocytes that contained multiple large intracytoplasmic eosinophilic inclusion bodies (molluscum bodies). These findings were consistent with a diagnosis of MC. Histopathologic examination of a biopsy specimen from a lichenified plaque on the forearm (not shown) revealed chronic eczematous dermatitis. The patient's laboratory data showed eosinophilia (2.5x10³/µL; reference value, <0.3x10³/µL) and an elevated IgE level (20 400 IU/mL; reference value, <100 IU/mL). The results of testing for anti–human immunodeficiency virus antibody were negative. Based on the clinical and microscopic findings, the patient was diagnosed as having hyper-IgE syndrome.

DISCUSSION

Molluscum contagiosum, a cutaneous infection that is caused by a DNA virus of the poxvirus family, most frequently presents as discrete, smooth, dome-shaped, flesh-colored papules. The individual lesions, which are usually 3 to 6 mm in diameter, are also characterized by a central umbilication. The lesions . . . [Full Text of this Article]

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Arch Dermatol. 2006;142(6):775-780.
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