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Sebaceous hyperplasia (SH), a benign proliferation of the sebaceous glands, develops as a consequence of aging, exposure to UV radiation, and immunosuppression. Organ transplant recipients are susceptible to SH,¹ particularly on the face, where multiple large lesions may cause cosmetic concern.

Report of a Case

A 43-year-old male renal transplant recipient receiving long-term immunosuppressive therapy developed more than 100 SH lesions on his face within 3 years of transplantation. He found these lesions particularly unsightly (Figure 1). Cryotherapy and carbon dioxide laser treatment provided some improvement, but the hypopigmentation that developed posttreatment was unsightly. Further treatment with these methods was not attempted.

Figure appears in full text version. Figure 1. Multiple facial lesions of sebaceous hyperplasia.

A single test treatment with a 1450-nm diode laser (Smoothbeam; Candela Corp, Wayland, Mass) was ineffective. Several lesions responded to treatment with topical 40% trichloroacetic acid, but hypopigmentation limited further treatment. Systemic isotretinoin could not be considered because of severe hypercholesterolemia.

The . . . [Full Text of this Article]

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AUTHOR INFORMATION
Conal M. Perrett, MRCP; Jane McGregor, MD, FRCP; Richard J. Barlow, MD, FRCP; Peter Karran, PhD; Charlotte Proby, MRCP; Catherine A. Harwood, PhD, MRCP