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Linear IgA disease (LAD) is an autoimmune subepidermal bullous disorder that may affect skin and/or mucous membranes. The presence of ocular involvement as the only manifestation of the disease is very rare.¹ We report a case of LAD that was limited to the eyes and progressed to bilateral blindness.

Report of a Case

A 75-year-old man with a 4-year history of eye disease presented in August 2000 with possible autoimmune blistering disease. Therapy with topical antibiotics and systemic corticosteroids had been ineffective. He stated that he had experienced redness, a burning sensation, and a reduction of visual acuity in his eyes over the past year. Ophthalmologic examination revealed conjunctival shrinking and scarring, cicatricial entropion, athrichiasis, and conjunctival injection (Figure 1), as well as symblepharon in the right lower fornix and erosion of the left cornea. The patient's skin, oral cavity, and genitalia were normal. Conjunctival biopsy revealed a subepithelial blister with fibrosis . . . [Full Text of this Article]

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AUTHOR INFORMATION
Carolina Talhari, MD; Christoph Althaus, MD; Mosaad Megahed, MD