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  Vol. 142 No. 7, July 2006 TABLE OF CONTENTS
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Slow-Growing Nodule on the Thigh—Diagnosis

Arch Dermatol. 2006;142:921.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Solitary fibrous tumor (SFT).

MICROSCOPIC FINDINGS

Histologic sections showed a well-circumscribed, nonencapsulated spindle cell tumor with a histologic pattern consisting of variably cellular areas composed of bland spindle cells separated by fine collagen. Cytologic atypia, necrosis, and mitotic figures were not identified. There were occasional dilated thin-walled vessels, although most were collapsed. The spindle cells were positive for CD34 and negative for S100 protein.

DISCUSSION

Solitary fibrous tumor is an unusual neoplasm of mesenchymal differentiation that was originally described in the pleura but has increasingly been found in a variety of cutaneous and subcutaneous locations, including the scalp, neck, cheek, back, and thighs, with sizes ranging from 1 to 4 cm in diameter.1-5 The tumor may derive from CD34+ dendritic interstitial cells, which are found in a wide variety of body sites, including the dermis.6 Histologically, it is a well-circumscribed but nonencapsulated neoplasm composed of bland, fine spindle cells separated by fine collagen. The cells may be . . . [Full Text of this Article]


RELATED ARTICLE

Slow-Growing Nodule on the Thigh—Quiz Case
Daniel B. Stewart, Barbara M. Egbert, Robert V. Rouse, and Susan M. Swetter
Arch Dermatol. 2006;142(7):921.
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