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RESEARCH LETTER
A Randomized, Placebo-Controlled, Double-blind Trial Comparing Narrowband UV-B Plus 0.1% Tacrolimus Ointment With Narrowband UV-B Plus Placebo in the Treatment of Generalized Vitiligo
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Narrowband UV-B (NB UV-B) therapy has recently been shown to be effective in the repigmentation of patients with vitiligo, without significant adverse effects. In recent uncontrolled studies, topical tacrolimus therapy has also been reported to cause repigmentation of vitiligo lesions, particularly on the face and neck. To explore the possibility of synergism between these 2 modalities, we conducted a prospective, randomized, controlled trial of therapy with NB UV-B and tacrolimus or placebo for patients with generalized vitiligo.
Methods
After local university institutional review board approval and informed consent were obtained, patients with the following inclusion criteria were recruited: generalized vitiligo (5%-50% body surface area); 2 paired vitiligo patches, at least 2 x 2 cm in greatest dimension, on each side of the body to serve as target lesions (areas classically resistant to treatment, such as the elbows, hands, knees, and feet were excluded); skin types III to VI; and stable disease . . . [Full Text of this Article] Results
Comment
AUTHOR INFORMATION
Don Mehrabi, MD;
Amit G. Pandya, MD
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Vitiligo
Taieb and Picardo
NEJM 2009;360:160-169.
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