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VIGNETTES
Skin Metastasis of Pancreatic Vasoactive Intestinal Polypeptide Tumor: Case Report and Review of the Literature
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Report of a Case
A 61-year-old man presented with a 3-week history of intractable diarrhea and a 20-lb (9-kg) weight loss. Abdominal computed tomography findings demonstrated a mass in the body of the pancreas and a few hepatic nodules. Results of fine-needle aspiration biopsy of the hepatic lesions revealed clusters of uniform polygonal cells with scant cytoplasm. The cells showed positive reaction to neuron-specific enolase and chromogranin consistent with a metastatic neuroendocrine tumor. Subsequently, the patient underwent irradiation and chemotherapy.
Four months later, the patient presented with a 2.5 x 1.5 x 1.0-cm tan to yellow nodule on the left forehead. Shave biopsy findings revealed an intraepidermal and dermal neoplasm composed of uniform, small to intermediate-sized cells in clusters, nests, and trabeculae. A few nests showed characteristic pseudorosette formation and had enlarged hyperchromatic nuclei and scant cytoplasm (Figure 1). The tumor was immunoreactive for cytokeratin, neuron-specific enolase, chromogranin, synaptophysin, vasoactive intestinal peptide, . . . [Full Text of this Article]
Comment
Conclusions
AUTHOR INFORMATION
Ramin Ram, BS;
Naveed Natanzi;
Payam Saadat, MD;
Daniel Eliav, BS;
Manjunath S. Vadmal, MD
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