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Arch Dermatol. 2006;142:1059-1064.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Angiosarcoma.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Microscopic examination of the biopsy specimen revealed an infiltrative and cellular proliferation of atypical endothelial cells, with formation of irregular vascular lumina. Tissue cultures were negative for bacterial and fungal pathogens. After the diagnosis of high-grade angiosarcoma was made, the patient underwent a staging workup, consisting of computed tomography of the head, neck, trunk, and pelvis. There was no evidence of either local invasion into the frontal bone or distant metastatic disease.

The patient subsequently underwent Mohs micrographic surgery for tumor extirpation. However, residual microscopic tumor remained in the periosteum. The resulting defect measured 8.0 x 9.0 cm and extended to the underlying frontal bone. Adjuvant treatment, including local radiation therapy and chemotherapy with paclitaxel (Taxol), was initiated in conjunction with the oncology and radiation oncology services.

DISCUSSION

Angiosarcomas are rare malignant tumors of vascular endothelial cells with a very high metastatic potential. Most cutaneous angiosarcomas develop in sun-damaged skin of . . . [Full Text of this Article]

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Arch Dermatol. 2006;142(8):1059-1064.
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