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RESEARCH LETTERS
Oxybutynin Therapy for Generalized Hyperhidrosis
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Hyperhidrosis is defined as sweating beyond what is necessary to maintain thermal regulation.1 Localized forms (eg, axillary, hands, feet, and craniofacial) can be distinguished from generalized forms.1 In generalized hyperhidrosis (GH), anticholinergic therapy would be a logical choice because acetylcholine is the effector sudomotor neurotransmitter. However, it is a widely held opinion that there is no place for these anticholinergic agents because of their adverse effects.1 The anticholinergic drug oxybutynin is registered for pollakisuria (urination at short intervals) and hyperreflectory urine bladder. The literature on the effect of oxybutynin on hyperhidrosis is anecdotal.2 We aimed to prospectively investigate the effectiveness and adverse effects of oxybutynin therapy for GH.
Methods
Fourteen adult patients with GH were recruited from June 2004 until May 2005. They received 2.5 mg of oral oxybutynin 3 times daily. Before and after 4 weeks of treatment, the impact of GH on daily life was assessed with the Dermatology . . . [Full Text of this Article]
Results
Comment
AUTHOR INFORMATION
Ron A. Tupker, MD;
Ankie M. Harmsze, PharmD;
Vera H. M. Deneer, PhD
RELATED LETTER
Treatment of Hyperhidrosis With Oxybutynin
Martine Schollhammer and Laurent Misery
Arch Dermatol. 2007;143(4):544-545.
EXTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Treatment of Hyperhidrosis With Oxybutynin
Schollhammer and Misery
Arch Dermatol 2007;143:544-545.
FULL TEXT
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