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A recent article titled "Intralesional Lipolysis With Phosphatidylcholine for the Treatment of Lipomas: Pilot Study," by Kopera et al,¹ contained fascinating and promising data about the treatment of lipomas by intralesional application of phosphatidylcholine (PTC). Based on 3 years of experience with the described technique, we would like to add some interesting observations.

First, in our opinion, lipolysis with PTC should not be seen as a therapy option for every patient with a lipoma. Rotunda et al² recently reported that sodium deoxycholate, a detergent component of injectable PTC formulation, causes nonspecific lysis of cell membranes. According to their in vitro observations that PTC formulas are dissolving not only fat cells but also muscle tissue, treating lipomas located near tendons, muscles, or nerves could potentially be dangerous, leading to possible necrosis of these vital structures. We therefore suggest that intramusucular lipomas and lipomas located near tendons and nerves represent a contraindication . . . [Full Text of this Article]

AUTHOR INFORMATION
Falk G. Bechara, MD; Michael Sand, MD; Peter Altmeyer, MD; Klaus Hoffmann, MD

RELATED ARTICLE

Intralesional Lipolysis With Phosphatidylcholine for the Treatment of Lipomas: Pilot Study—Reply
Daisy Kopera
Arch Dermatol. 2006;142(8):1070.
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