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Tacrolimus and Pimecrolimus for Atopic Dermatitis
Where Do They Fit In?
Michael Bigby, MD
Arch Dermatol. 2006;142:1203-1205.
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Commentary on: Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomized controlled trials
Ashcroft DM, Dimmock P, Garside R, Stein K, Williams HC
BMJ. 2005;330:516; doi:10.1136/bmj.38376.439653.D3
Question: For adults and children with atopic dermatitis, which are more effective and better tolerated in reducing the signs and symptoms of atopic dermatitis: topical pimecrolimus, tacrolimus, corticosteroids, or vehicle?
Design: Systematic review and meta-analysis.
Data Sources: Electronic searches of the Cochrane Library database, MEDLINE, and EMBASE.
Study Selection: Randomized controlled trials of topical pimecrolimus or tacrolimus reporting efficacy outcomes or tolerability.
Outcomes: Efficacy: investigators' global assessment of response; patients' global assessment of response; percentages of patients with flares of atopic dermatitis; and improvements in quality of life. Tolerability: overall rates of withdrawal; withdrawal owing to adverse events; and percentages of patients with burning of the skin and with skin infections.
. . . [Full Text of this Article] Comment
AUTHOR INFORMATION
Department of Dermatology, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Mass
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Sinéad M. Langan, Kim S. Thomas, and Hywel C. Williams
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