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Reflections on Eosinophils and Flame Figures
Where There's Smoke There's Not Necessarily Wells Syndrome
Arch Dermatol. 2006;142:1215-1218.
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Eosinophils were first described in 1879 by Paul Ehrlich, who recognized their ability to stain with acid dyes, particularly eosin. The distinctive tinctorial properties of eosinophil granules give these cells a prominence in stained sections that contrasts with their lack of diagnostic power and still undefined role in pathogenesis. Eosinophils may be seen in skin biopsy specimens from patients with various inflammatory and neoplastic disorders, but they are among the diagnostic criteria in a limited number of diseases, including Wells syndrome, angiolymphoid hyperplasia with eosinophilia, and eosinophilic pustulosis.1-2
Eosinophils are associated with pathophysiologic mechanisms that strongly implicate them in the pathogenesis of many cutaneous diseases. Eosinophil involvement has been well documented in cutaneous disorders characterized by swelling,3 particularly chronic urticaria,4 pressure urticaria,5 and episodic angioedema.6 Cutaneous edema was the common clinical thread in the first 4 cases reported by Wells.7 Eosinophils also have a role in eczematoid dermatoses such as . . . [Full Text of this Article]
AUTHOR INFORMATION
Kristin M. Leiferman, MD;
Margot S. Peters, MD
RELATED ARTICLE
Wells Syndrome in Adults and Children: A Report of 19 Cases
Ruggero Caputo, Angelo V. Marzano, Pamela Vezzoli, and Luisa Lunardon
Arch Dermatol. 2006;142(9):1157-1161.
ABSTRACT
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