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Follicular graft-vs-host disease (GVHD) was probably first reported in 1984.¹ Clinically acute follicular GVHD was described as an eruption similar to a bacterial or fungal folliculitis following allogenic bone marrow transplantation (BMT).² Cases of clinically acute and chronic follicular GVHD have been described.^3-6 We report the unexpected finding of follicular lichenoid GVHD in a biopsy specimen from a nonspecific lesion that appeared on a patient on the 18th day after BMT.

Report of a Case

A 39-year-old woman with acute lymphocytic leukemia, L₂type, Philadelphia chromosome positive, and common acute lymphoblastic leukemia antigen positive, in complete remission was treated with an HLA-matched allogenic BMT from her brother following conditioning with intravenous cyclophosphamide (60 mg/kg per day) on days 6 and 5 before BMT and total body irradiation from days 4 to 1 before BMT. Prophylactic treatment against GVHD included intravenous cyclosporin A (1.5 mg/kg every 12 hours) from day 0 and methotrexate, 15 mg/m² . . . [Full Text of this Article]

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AUTHOR INFORMATION
Rebeca Goiriz, MD; Yolanda Delgado-Jiménez, MD; Pablo Fernández-Peñas, MD, PhD; Javier Fraga, MD, PhD; Amaro García-Diez, MD, PhD; Jesús Fernández-Herrera, MD, PhD

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