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Kabir Sardana, MD, DNB, MNAMS; Premanshu Bhushan, MD; Vijay Kumar Garg, MD, MNAMS

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with interest the article by Ostovari et al,¹ who elegantly surmised that UV light is essential for tacrolimus to work. In our vitiligo clinic we have been studying the pattern of repigmentation of vitiligo with tacrolimus, the stability of this pigment, and the site variation for the last 2 years. We believe that there is sufficient evidence to show that tacrolimus monotherapy is useful to produce repigmentation.²

At the molecular level, a study by Lan et al² to assess the effects of tacrolimus revealed that proliferation of both melanocyte and melanoblasts was significantly enhanced by tacrolimus. In addition, the concentration of stem cell factor in keratinocytes supernatant increased in a dose-dependent manner with tacrolimus treatment.² This provides in vitro evidence demonstrating that direct interaction between tacrolimus and keratinocytes creates a favorable milieu for melanocyte growth . . . [Full Text of this Article]

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RELATED LETTERS

Lack of Efficacy of Tacrolimus in the Treatment of Vitiligo in the Absence of UV-B Exposure
Nima Ostovari, Thierry Passeron, Jean-Philippe Lacour, and Jean-Paul Ortonne
Arch Dermatol. 2006;142(2):252-253.
EXTRACT | FULL TEXT  

Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure—Reply
Thierry Passeron and Jean-Paul Ortonne
Arch Dermatol. 2007;143(1):120.
EXTRACT | FULL TEXT