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COMMENTS AND OPINIONS
Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure—Reply
Thierry Passeron, MD;
Jean-Paul Ortonne, MD
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In reply
Sardana and colleagues raise very important points to consider about the efficacy of tacrolimus in treating vitiligo. We agree that tacrolimus induces several effects at the molecular level that might enhance the repigmentation of vitiligo-affected skin. Unfortunately, in vitro studies do not always determine the full effect of a molecule applied to skin and are not sufficient to prove its efficacy. Nonetheless, several clinical studies have evaluated the potential of tacrolimus for treating vitiligo.
Members of our research group1 and Kawalek et al2 have shown that the combination therapy of tacrolimus and 308-nm excimer laser produces significantly better results than the laser alone. These data support a positive role of tacrolimus for repigmenting vitiligo lesions. However, the aim of the study by our group3 that prompted the letter by Sardana et al was to evaluate the efficacy of tacrolimus as a true . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTERS
Lack of Efficacy of Tacrolimus in the Treatment of Vitiligo in the Absence of UV-B Exposure
Nima Ostovari, Thierry Passeron, Jean-Philippe Lacour, and Jean-Paul Ortonne
Arch Dermatol. 2006;142(2):252-253.
EXTRACT
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Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure
Kabir Sardana, Premanshu Bhushan, and Vijay Kumar Garg
Arch Dermatol. 2007;143(1):119.
EXTRACT
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RELATED ARTICLE
Topical Tacrolimus and the 308-nm Excimer Laser: A Synergistic Combination for the Treatment of Vitiligo
Thierry Passeron, Nima Ostovari, Wassim Zakaria, Eric Fontas, Jean-Claude Larrouy, Jean-Philippe Lacour, and Jean-Paul Ortonne
Arch Dermatol. 2004;140(9):1065-1069.
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