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  Vol. 143 No. 10, October 2007 TABLE OF CONTENTS
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VIGNETTES
Delayed Wound Healing Following Treatment With Low-Dose Interferon Alfa-2b for Cutaneous Melanoma

Alfred F. Ammoury, MD; Fouad El Sayed, MD; Jacques Bazex, MD

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Adjuvant therapies for cutaneous melanoma have been well studied, and to our knowledge only high-dose interferon alfa-2b shows reproducible benefit.1 Efforts to improve the toxic effects profile of high-dose regimens have included the use of lower doses. We report a case of delayed wound healing secondary to treatment with low-dose interferon alfa-2b for cutaneous melanoma.

Report of a Case

A 23-year-old woman, skin phototype II, presented with a 3-month history of a slowly growing, nodular, achromic lesion on the left calf. Apart from frequent sunburn, she had been well. Histologic examination revealed an ulcerated superficial spreading melanoma 4.8-mm thick, Clark level 4, without signs of regression. Her treatment consisted of a 3-cm-wide excision followed by LLL-plasty. Sentinel lymph node dissection of the left inguinal region revealed 3 nonmetastatic lymph nodes. The disease was classified as a stage IIC (2002 American Joint Committee on . . . [Full Text of this Article]


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