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Recurrent Calcified Cutaneous Nodule of the Perianal Region—Diagnosis
Arch Dermatol. 2007;143(11):1441-1446.
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Diagnosis: Cutaneous malakoplakia.
MICROSCOPIC, LABORATORY, AND RADIOLOGIC FINDINGS
The biopsy specimen showed a diffuse, predominantly histiocytic infiltrate mixed with rare neutrophils and lymphocytes. The histiocytes had distinct cellular borders and granular cytoplasm that stained with periodic-acid–Schiff and were immunopositive for CD68. Many of the histiocytes contained concentric intracytoplasmic, basophilic, calcified spherules characteristic of Michaelis-Gutmann bodies (Figure 3, arrows)
Figure appears in full text version.
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Gram stain and bacterial cultures did not identify any bacteria. Additional blood work did not reveal any evidence of immunosuppression, autoimmune disease, chronic hepatitis, or diabetes mellitus. Because embryonic abnormalities, such as a lumbosacral lipoma or a cyst, were suspected, magnetic nuclear resonance imaging was performed and revealed occult spinal dysraphism involving all sacral vertebrae.
DISCUSSION
Malakoplakia, an inflammatory disease characterized by granulomatous accumulation of distinctive phagocytic macrophages, occurs mainly in the mucosa of the urinary tract, while cutaneous involvement is very rare. To our knowledge, about 41 cases of cutaneous malakoplakia have been described to date, . . . [Full Text of this Article]
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Recurrent Calcified Cutaneous Nodule of the Perianal Region—Quiz
Annalisa Patrizi, Federica Giacomini, Federica Bianchi, Cosimo Misciali, and Iria Neri
Arch Dermatol. 2007;143(11):1441-1446.
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