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Generalized Papules in a Patient With Acute Myeloid Leukemia—Diagnosis
Arch Dermatol. 2007;143(12):1583-1588.
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Diagnosis: Fungal emboli due to systemic Candida krusei infection.
MICROSCOPIC FINDINGS AND CLINICAL COURSE
The skin biopsy specimen showed microabscesslike clusters of eosinophilic small round bodies within the blood vessels of the upper dermis. Periodic acid–Shiff and Grocott stains showed that these small bodies were positive for microorganisms. There were no microorganisms in the corneal layer. Parakeratosis, subtle dyskeratosis in the epidermis, and vacuolar change in the basal layer were also seen. A blood culture yielded Candida krusei. Based on these findings, we diagnosed these eruptions as fungal emboli due to systemic C krusei infection.
After the diagnosis, his central venous catheter was removed and his antifungal drugs were changed to voriconazole and micafungin because C krusei is resistant to fluconazole. The eruptions improved, but he had resistant fever. Chest and abdominal computed tomography detected multiple low-density areas in the lungs and liver that were clinically due to systemic C krusei infection. Because C krusei in our case was sensitive to amphotericin B . . . [Full Text of this Article] DISCUSSION
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Arch Dermatol. 2007;143(12):1583-1588.
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