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Cinacalcet for the Treatment of Calciphylaxis
Maria R. Robinson, MD;
Joshua J. Augustine, MD;
Neil J. Korman, MD, PhD
Arch Dermatol. 2007;143(2):152-154.
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INTRODUCTION
Calciphylaxis is characterized by cutaneous ischemia and necrosis and is associated with a very high mortality rate. It usually affects patients who are undergoing dialysis or who have received a kidney transplant. There is no optimal treatment, but parathyroidectomy has shown some benefit. We report herein a case of a patient with calciphylaxis and secondary hyperparathyroidism who was successfully treated with cinacalcet hydrochloride, a calcimimetic.
REPORT OF A CASE
A 62-year-old man was admitted to the hospital for gastrointestinal bleeding and was found to have an elevated international normalized ratio. The patient had a medical history of chronic nephrolithiasis from long-standing Crohn disease that required an ileostomy and end-stage renal disease that had resulted in a kidney transplant 2 years prior to presentation. During his hospitalization, the dermatology department was consulted because the patient had painful bilateral thigh ulcers, which had . . . [Full Text of this Article]
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
AUTHOR INFORMATION
Departments of Dermatology (Drs Robinson and Korman) and Medicine, Division of Nephrology and Hypertension (Dr Augustine), University Hospitals Case Medical Center, Cleveland, Ohio
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Sodium Thiosulfate as First-Line Treatment for Calciphylaxis
Felix Ackermann, Annabelle Levy, Eric Daugas, Noel Schartz, Anne Riaux, Christian Derancourt, Pablo Urena, and Celeste Lebbé
Arch Dermatol. 2007;143(10):1336-1337.
EXTRACT
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Sodium Thiosulfate as First-Line Treatment for Calciphylaxis—Reply
Maria R. Robinson, Joshua J. Augustine, and Neil J. Korman
Arch Dermatol. 2007;143(10):1338.
EXTRACT
| FULL TEXT
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Calciphylaxis Responding to Sodium Thiosulfate Therapy
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Arch Dermatol. 2007;143(2):269-270.
EXTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Calciphylaxis from Nonuremic Causes: A Systematic Review
Nigwekar et al.
CJASN 2008;3:1139-1143.
ABSTRACT
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Sodium Thiosulfate as First-Line Treatment for Calciphylaxis
Ackermann et al.
Arch Dermatol 2007;143:1336-1337.
FULL TEXT
Sodium Thiosulfate as First-Line Treatment for Calciphylaxis Reply
Robinson et al.
Arch Dermatol 2007;143:1338-1338.
FULL TEXT
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