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  Vol. 143 No. 2, February 2007 TABLE OF CONTENTS
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  The Cutting Edge: Challenges in Medical and Surgical Therapeutics
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 •Dermatology
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Cinacalcet for the Treatment of Calciphylaxis

Maria R. Robinson, MD; Joshua J. Augustine, MD; Neil J. Korman, MD, PhD

Arch Dermatol. 2007;143(2):152-154.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Calciphylaxis is characterized by cutaneous ischemia and necrosis and is associated with a very high mortality rate. It usually affects patients who are undergoing dialysis or who have received a kidney transplant. There is no optimal treatment, but parathyroidectomy has shown some benefit. We report herein a case of a patient with calciphylaxis and secondary hyperparathyroidism who was successfully treated with cinacalcet hydrochloride, a calcimimetic.


REPORT OF A CASE

A 62-year-old man was admitted to the hospital for gastrointestinal bleeding and was found to have an elevated international normalized ratio. The patient had a medical history of chronic nephrolithiasis from long-standing Crohn disease that required an ileostomy and end-stage renal disease that had resulted in a kidney transplant 2 years prior to presentation. During his hospitalization, the dermatology department was consulted because the patient had painful bilateral thigh ulcers, which had . . . [Full Text of this Article]

THERAPEUTIC CHALLENGE

SOLUTION

COMMENT

AUTHOR INFORMATION

Departments of Dermatology (Drs Robinson and Korman) and Medicine, Division of Nephrology and Hypertension (Dr Augustine), University Hospitals Case Medical Center, Cleveland, Ohio



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RELATED LETTERS

Sodium Thiosulfate as First-Line Treatment for Calciphylaxis
Felix Ackermann, Annabelle Levy, Eric Daugas, Noel Schartz, Anne Riaux, Christian Derancourt, Pablo Urena, and Celeste Lebbé
Arch Dermatol. 2007;143(10):1336-1337.
EXTRACT | FULL TEXT  

Sodium Thiosulfate as First-Line Treatment for Calciphylaxis—Reply
Maria R. Robinson, Joshua J. Augustine, and Neil J. Korman
Arch Dermatol. 2007;143(10):1338.
EXTRACT | FULL TEXT  

RELATED ARTICLE

Calciphylaxis Responding to Sodium Thiosulfate Therapy
Brian L. Baker, Carrie A. Fitzgibbons, and Lucinda S. Buescher
Arch Dermatol. 2007;143(2):269-270.
EXTRACT | FULL TEXT  


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Calciphylaxis With Normal Renal and Parathyroid Function: Not as Rare as Previously Believed
Kalajian et al.
Arch Dermatol 2009;145:451-458.
ABSTRACT | FULL TEXT  

Sodium thiosulfate, bisphosphonates, and cinacalcet for treatment of calciphylaxis
Raymond and Wazny
Am J Health Syst Pharm 2008;65:1419-1429.
ABSTRACT | FULL TEXT  

Calciphylaxis from Nonuremic Causes: A Systematic Review
Nigwekar et al.
CJASN 2008;3:1139-1143.
ABSTRACT | FULL TEXT  

Sodium Thiosulfate as First-Line Treatment for Calciphylaxis
Ackermann et al.
Arch Dermatol 2007;143:1336-1337.
FULL TEXT  

Sodium Thiosulfate as First-Line Treatment for Calciphylaxis Reply
Robinson et al.
Arch Dermatol 2007;143:1338-1338.
FULL TEXT  





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