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The Yin and Yang of TNF- Inhibition

David F. Fiorentino, MD, PhD

Arch Dermatol. 2007;143(2):233-236.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Few will argue that the availability of tumor necrosis factor (TNF-) blocking agents has significantly altered the way dermatologists manage disease in patients with moderate to severe psoriasis. Even for physicians who do not use these agents in their practice, the finding that TNF- inhibitors uniquely arrest destructive joint progression is something that must be considered for patients with significant psoriatic joint disease.

The utility of these agents, however, goes beyond improving the clinical care of our patients. With specifically targeted agents in clinical practice, we now have the ability to observe human "knockouts" on a large scale for the first time in history. It is often by observing the side effects or nonresponders that we are able to increase our understanding of a disease process.

The 2 articles by Ubriani and Van Voorhees¹ and de Gannes et al² in this issue of A. . . [Full Text of this Article]

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