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David T. Woodley, MD

Arch Dermatol. 2007;143(2):249-250.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Mapping the Binding Sites of Anti-BP180 IgE Autoantibodies in Bullous Pemphigoid
Fairley JA, Ling Fu C, Giudice GJ
J Invest Dermatol. 2005;125:467-472

Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal protein BP180 (BPAg2, type XVII collagen). NC16A, a noncollagenous stretch of the BP180 ectodomain, is the primary target of pathogenic IgG autoantibodies and IgE class autoantibodies. This study further characterized the IgE-reactive regions of BP180. Of ten sera from untreated BP patients, eight contained IgE reactive with the entire BP180 ectodomain. The IgE in 4 of these 8 sera reacted with NC16A, while in the remaining 4 sera IgE immunoreactivity was restricted to sites downstream of NC16A. In contrast, IgG reactivity to NC16A was detected in 9 of the 10 BP sera, and in the remaining serum, IgG, as well as IgE, reacted exclusively with non-NC16A sites on the . . . [Full Text of this Article]

COMMENT

AUTHOR INFORMATION

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles

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