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Gary S. Wood, MD, Section Editor

Arch Dermatol. 2007;143(2):253-254.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of the ARCHIVES, Woodley¹ discusses new advances in our understanding of the pathogenesis of bullous pemphigoid (BP). He uses the On the Horizon section to highlight a recent study by Fairley et al² on the role of IgE class autoantibodies in this disorder. As he notes, there is now evidence that IgE autoantibodies directed against the NC-16A domain of BP180/type XVII collagen in the basal keratinocyte hemidesmosome can mediate mast cell degranulation and eosinophil chemotaxis. These findings are important because they provide a mechanistic basis for the pruritus, urticaria, and eosinophilic spongiosis that typify early BP clinicopathologically. They are also important because they suggest new approaches for the treatment of this vexing condition.

Figure appears in full text version. Section Editor and Assistant Section Editors, On the Horizon

On the Horizon is designed precisely for this purpose: To showcase a recent finding in the scientific . . . [Full Text of this Article]

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